Cat & Dog - SAMe Products e.g. Zentonil, Doxion, Hepatocyl, Samylin
What is SAMe?
SAMe (S-adenosylmethionine) is naturally made by cells throughout the body and is formed from the amino acid (protein building block) methionine and a cellular energy substance called ATP. It is also found naturally in food sources like meat and sunflower seeds.
SAMe is an antioxidant and has detoxifying properties, primarily in the liver. It can reduce high liver enzyme levels found on blood tests (that show some degree of liver inflammation [hepatitis] or even the severe liver problem cirrhosis). It has been shown in research to increase glutathione levels; glutathione is a powerful antioxidant which helps maintain and protect liver function. It is mainly used as a liver support supplement in veterinary practice today, although it has also been used for dogs with osteoarthritis.
Why recommend administration of SAMe to my pet?
SAMe products are almost exclusively used to help in liver disease in veterinary medicine.
How safe is SAMe?
Side effects of SAMe are very rare, and limited to mild nausea and gastrointestinal irritation at high doses.
Where do I obtain SAMe and do I need a prescription?
Please talk to one of the vets if you would like to discuss the use of these products.
© Copyright 2025 LifeLearn Inc. Used and/or modified with permission under license. This content written by LifeLearn Animal Health (LifeLearn Inc.) is licensed to this practice for the personal use of our clients. Any copying, printing or further distribution is prohibited without the express written consent of LifeLearn. This content does not contain all available information for any referenced medications and has not been reviewed by the FDA Center for Veterinary Medicine, or Health Canada Veterinary Drugs Directorate. This content may help answer commonly asked questions, but is not a substitute for medical advice, or a proper consultation and/or clinical examination of your pet by a veterinarian. Please contact your veterinarian if you have any questions or concerns about your pet’s health. Last updated on Jan 31, 2013.